Carmen Guerra, PhD
Dr. Guerra studies genetic and pharmacological therapeutic strategies against pancreatic cancer in genetically modified mouse models (GEMMs) that recapitulate human disease. The identification of possible therapeutic targets is carried out both in tumor cells and in the stroma of pancreatic cancer tumors. Specifically, stromal studies are focused on defining at a molecular and functional level the different populations of cancer associated fibroblasts. After the validation of the targets in preclinical trials in GEMMs, the targets are validated in tumor samples of patients, both in organoids and in tumors of patients implanted in immunosuppressed mice (PDX).