Postdoctoral Fellows
Vasiliki Liaki, PhD
lvasiliki@cnio.es
vasiliki-liaki
Dr. Vasiliki Liaki specializes in molecular therapeutics of pancreatic ductal adenocarcinoma. She conducts bioinformatic analyses to translate big data to targeted therapies. She also performs preclinical studies with mouse models and human-derived samples using genetic and pharmacological approaches. She has recently validated the efficacy of a new therapeutic strategy based on the combined inhibition of EGFR, RAF1 and STAT3. Currently, she is investigating the molecular mechanisms of advanced and metastatic pancreatic cancer, as these highly aggressive tumors have nowadays no treatment options.
Carolina Villaroya, PhD
cvillarroya@cnio.es
carolina-villaroya-beltri
Dr. Carolina Villarroya focus her research in the development of new therapies against non-small cell lung cancer. A high proportion of these cancers are caused by mutations in the KRAS gene, which leads to its permanent activation. The inhibition of KRAS mutants or other genes involved in the same pathway induces tumor regression, but some tumors are naturally resistant to these therapies and other develop resistance with time. Based on the CRISPR/CAS9 system, we aim to discover these mechanisms of resistance and to identify new targets which combined inhibition with KRAS pathway efficiently induce complete tumor regression.
